Internationally, the quality standards for L-HPC are jointly regulated by the USP (United States Pharmacopeia), EP (European Pharmacopeia), and JP (Japanese Pharmacopeia). Core indicators include:
Degree of Substitution: 5%-16% (low substitution range)
Viscosity: 5-50 mPa·s at 20℃ for a 2% aqueous solution (varies by type)
Loss on Drying: ≤5% (reflects moisture content)
Heavy Metal Content: ≤10ppm (ensuring safety) Domestic production must comply with GB 1886.315-2021 "National Food Safety Standard - Food Additives - Low-Substitution Hydroxypropyl Cellulose," with particularly stringent requirements for microbiological indicators (e.g., total bacterial count ≤1000 CFU/g).
